TLR4 and necrotizing enterocolitis: Some studies found an association between NEC and variants in regulators of the Toll-Like-Receptor 4 (TLR4) signalling pathway, NFκ-B1 variants, SNPs of IL-6 gene, NOD2 mutations, IL17F, and the allele of the autophagy (ATG) genes ATG16L1 [13].