While there is little evidence that PE beneficially alters the expression levels of specific circRNAs in the nervous system, one study found that aerobic exercise enhanced cognitive ability by reducing neuronal apoptosis via the circRIMS2/miR‐186/BDNF pathway in a VCI model,10 suggesting that PE‐induced circRNAs may promote rehabilitation from cerebrovascular diseases. Here, BDNF is linked to cerebrovascular disorder.