Over20 adult neurodegenerative diseases, such as Alzheimer’sdisease (AD), are characterized by the dysfunction and accumulationof tau protein.1−4 However, the molecular mechanisms that induce tau misfolding andaggregation in neurodegenerative disorders remain elusive.5 Tau protein post-translational modifications(PTMs) are associated with the development of AD, such as phosphorylation,acetylation, and methylation.6−9 Therefore, a complete picture of the PTM landscapeof tau is critical for understanding the roles played by tau proteinin modulating AD progression. This evidence concerns the gene MAPT and neurodegenerative disease.