In addition to the strong NIR emission (λex = 430 nm) that allows localization of the metallopeptide in the lysosomes of blader cancer cells, the incorporation of the porphyrin unit provides a multimodal agent for its use in photodynamic therapy via1O2 generation that kills cancer cells.95 Later, the incorporation of a DO3A–aryl–alkynyl–pyridine–Yb(iii) complex at the N-terminus of peptide P19 through a copper(i)-catalyzed alkyne–azide cyclo-addition afforded the corresponding YbP19 metallopeptide, which was designed to bind latent membrane protein 1 (LMP1). Here, PDLIM7 is linked to cancer.