ZFP36 and cancer: The sensor is based on the tristetraprolin (TTP) protein family, which binds this RNA as part of their role in the regulation of inflammation and cancer.63 More specifically, the designed LTISTb metalloprotein is a 68 amino acid sequence, based on the RNA binding domain of the TIS11d protein of the TTP family, consisting of two zinc finger domains separated by a 10-residue flexible linker.