GFAP and Huntington disease: The present investigation showed an upsurge in the immunohistochemical expression of GFAP following 3NP administration which is in line with previous reports demonstrating elevation of striatal GFAP immunohistochemical expression in response to 3NP systemic administration in HD rat models (Elbaz et al. 2019; Ibrahim and Abdel Rasheed 2022).