Several reports have demonstrated how Nrf2 activation, through its release from binding to Keap1 protein, protects against oxidative stress in both in vitro and in vivo models of neurodegenerative disease (Brandes and Gray 2020; Dinkova-Kostova et al. 2018), including 3NP-induced HD’s like disease in rats (Gonchar et al. 2021). This evidence concerns the gene NFE2L2 and neurodegenerative disease.