The low Nrf2 levels reported herein following 3NP-intoxication may be a factor contributing to the increased NF-κB p65 gene expression, These results are corroborated by several studies in HD-like rat model (Gendy et al. 2023; Ibrahim and Abdel Rasheed 2022; Jang and Cho 2016; Mansour et al. 2022). Here, NFE2L2 is linked to Huntington disease.