For example, total fat mass is a major risk factor for T2D and potentially causally related to carboxypeptidase M (β = 0.04, 95% CI 0.02 to 0.06), which in turn was strongly associated with incident T2D (hazards ratio (HR) 2.04, 95% CI 1.54 to 2.67). The gene discussed is CPM; the disease is type 2 diabetes mellitus.