TBP and spinocerebellar ataxia type 17: SCA17 -Spinocerebellar Ataxia 17- is caused by Poly-Q increase in the TATA Binding Protein, TBP: two papers reported on a scenario similar to HD and SBMA, namely increased binding of mut-TBP to NF-YA, matched by decreased expression of chaperon genes -HSP70, HSPA5- which worsens the outlook of the disease by increasing the production and deposition of insoluble toxic aggregates in neurons [141, 142].