Both excessive and insufficient expression of Cadm4 and Cadm3 can disrupt the myelination process, leading to impaired nerve function and contributing to various neurological disorders.7,8 One notable condition associated with disrupted Cadm4 function is Charcot-Marie-Tooth (CMT) neuropathy,13 a hereditary demyelinating disease characterized by progressive muscle weakness and sensory loss. Here, CADM4 is linked to nervous system disorder.