GSDMD and hydrops fetalis: Consistent with these findings, Suetomi et al. found that both Il1b and Nlrp3 are upregulated in pressure-overloaded mice,49 and other studies found that activation of the NLRP3 inflammasome complex results in IL-1β production50 and pyroptotic cell death.51,52 Here, we show that loss of Nlrp3 reduces TAC-induced cardiac cell death, but we did not explicitly demonstrate that this effect is mediated by GSDMD-mediated pyroptosis; therefore, although we claim that pyroptotic signaling is involved in TAC-mediated HF, further works are needed to examine whether pyroptosis also plays a role.