ACSL4 and cardiac hypertrophy: Moreover, we found that the expression of Il1b and Nlrp3 (which encode the cytokine IL-1β and the pyrin-like protein NLR family pyrin domain containing 3, respectively) were significantly upregulated in TAC-induced cardiac hypertrophy in Acsl4 F/F mice, but not in Acsl4 KO mice (Fig. 6c).