The ANT family was found to interact with the subunits of various electron transport chain complexes to perform their functions.34,35 Interestingly, ANT2 expression was greater in BAT than in subcutaneous and visceral WAT of non-tumour-bearing mice, as previously described,33 and the interaction of ANT2 with UCP1 was determined using coimmunoprecipitation experiments followed by mass spectrometry (Supplementary Fig. 7a, b). Here, UCP1 is linked to neoplasm.