Surprisingly, gene ontology (GO) enrichment analysis revealed that nearly 20% of these proteins were classified as mitochondrial components (Fig. 3a), and almost half of these were heat shock proteins (HSP90, HSP70, GRP75, and GRP78), suggesting that tumour-secreted mitochondrial components may be associated with adipocyte browning. The gene discussed is HSPA5; the disease is neoplasm.