UCP1 and neoplasm: The activation of the browning process in adipocytes can lead to elevated expression of thermogenesis genes, such as UCP1, as well as the upregulation of oxygen consumption and mitochondrial biogenesis.31 Immunoblotting revealed increased levels of exogenous GRP75 in mitochondria isolated from adipocytes treated with GRP75-overexpressing EVs (Supplementary Fig. 3g), suggesting that tumour-derived GRP75 can be internalized by mitochondria.