Multiple studies have shown increased UCP1 expression in the WAT of cachectic mice and patients,8,15,16 and ablation of UCP1 could mitigate symptoms associated with cancer cachexia, including body weight loss and muscle wasting.41 This evidence indicates the importance of UCP1-induced increases in energy expenditure for cachexia-associated wasting. This evidence concerns the gene UCP1 and Cachexia.