Upregulation of GRP75 was detected in the iWAT and serum of LLC tumour-bearing mice (Supplementary Fig. 4f–g), and there was an inverse correlation between the serum GRP75 concentration and the WAT/NBW ratio (Supplementary Fig. 4h, R2 = 0.5234, P < 0.0001). Here, HSPA9 is linked to neoplasm.