Within the first week of critical illness, patients lose approximately 2% of their muscle cross‐sectional area, which in the second week increases to about 30% loss (Fazzini et al., 2023) The murine model of ALI‐associated muscle wasting robustly displays many key features of human critical illness‐associated muscle wasting, including myosin loss and type 2 myofiber atrophy (Files et al., 2012). Here, MYH14 is linked to acute respiratory distress syndrome.