Here, we report on a maturationprocess for the cellular prion protein (PrPC) that involvesa conformational change after LLPS and is regulated by mutations andpoly(4-styrenesulfonic acid-co-maleic acid) (PSCMA),a molecule that has been reported to rescue Alzheimer’s disease-relatedcognitive deficits by antagonizing the interaction between PrPC and amyloid-β oligomers (Aβo). This evidence concerns the gene PRNP and early-onset autosomal dominant Alzheimer disease.