As we observed that hypoxia or NRF2 downregulation induces a deleterious effect on expression of genes involved in GSH synthesis (SLC7A11, GSR, GCLC, GCLM, and SLC3A2; Fig. 3, A, B and D), we further investigated the role of this pathway in HE-derived hematopoiesis. This evidence concerns the gene GCLM and hereditary elliptocytosis.