FNDC4 and inflammatory bowel disease: For example, we can speculate and experimentally verify that supplementing with exogenous rFNDC protein can improve intestinal inflammation in IBD and have therapeutic effects on aging hearts; On the contrary, inhibiting FNDC4 through targeted drugs may inhibit the invasion and metastasis of HCC; In addition, FNDC4 can promote the generation of adipocyte mitochondria and browning of white adipocytes, inhibit inflammation and ER stress to improve insulin resistance.