For example, we can speculate and experimentally verify that supplementing with exogenous rFNDC protein can improve intestinal inflammation in IBD and have therapeutic effects on aging hearts; On the contrary, inhibiting FNDC4 through targeted drugs may inhibit the invasion and metastasis of HCC; In addition, FNDC4 can promote the generation of adipocyte mitochondria and browning of white adipocytes, inhibit inflammation and ER stress to improve insulin resistance. This evidence concerns the gene FNDC4 and hepatocellular carcinoma.