We assessed the bidirectional causal relationship between thyroid disease traits (hyperthyroidism and hypothyroidism), thyroid hormone level traits (TSH and FT4), and two PA/SB-related indicators (LST and MVPA) using two-sample MR tests with the most comprehensive thyroid disease consortium data [21] and the most recent large-scale genome-wide association study (GWAS) meta-analysis data for PA/SB [22]. This evidence concerns the gene TG and hyperthyroidism.