Miao et al. demonstrated that Wnt/β-catenin and RAS activity are upregulated in the aging kidney, while Klotho, acting as an antagonist of endogenous Wnt/β-catenin activity, attenuates d-galactose-induced renal fibrosis in a mouse model of accelerated aging, safeguarding renal mitochondrial function by curtailing reactive oxygen species production [30]. This evidence concerns the gene KL and renal fibrosis.