Moreover, the expression level of the tubular epithelial cell marker E-calmodulin (E-cadherin) was significantly decreased in the renal tissue of group A (P<0.05), and that of the renal interstitial markers a-SMA and fibronectin was significantly increased (P<0.01), indicating that aging was accompanied by renal fibrosis. This evidence concerns the gene FN1 and renal fibrosis.