IR resulted in a pronounced inhibition of tumor growth in Ythdf1-cKO mice compared with WT mice, as assessed by both tumor volume and animal survival, in both MC38 colon carcinoma and B16-SIINFEKL(OT-I)-Zsgreen (B16-OZ) melanoma models (Figure 1, C–F). The gene discussed is YTHDF1; the disease is melanoma.