FOXO1 and neoplasm: While strong nuclear immunoreactivity for total and phosphorylated/inactivated FOXO1 characterized the tumor compartment and the adjacent nontumorous surrounding liver tissues, only the tumor lesions displayed robust cytoplasmic immunolabeling for the 2 proteins (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI174415DS1).