MYC and neoplasm: Consistent with the results from the Foxo1Rictor double-KO studies, both c-MYC/FOXO1AAA and c-MYC/pT3-EF1α mice developed a high tumor burden and had to be euthanized by 6–9 weeks after injection, suggesting that activated FoxO1 did not improve the survival of c-MYC mice (Figure 2B).