It is clear from the data presented in Fig. 4d, that expression of RUNX1 and TIMP1 is slightly higher in IBD patients as compared to normal, whereas the expression of both genes increases three- to fourfolds as CRC develops and progresses and follow the following expression pattern: normal < IBD < tumour < metastasis, thus providing a capability to monitor progression of IBD to CRC. The gene discussed is TIMP1; the disease is inflammatory bowel disease.