Expression of RUNX1 seems to vary from study to study where it has been found to be downregulated (Wu et al. 2020), or upregulated in CRC tissues (similar to our preliminary validation as well as the in silico validation (Fig. 3, 4) and its variants to be associated with increased risk for colon and rectal carcinogenesis (Zhou et al. 2017). The gene discussed is RUNX1; the disease is colorectal carcinoma.