By this, findings on chemotherapy-induced EV miRNAs in leukaemia are rare at present, but bone marrow microenvironment stromal cells have been reported to downregulate miR-23a-5p levels in AML cells to protect them from the chemotherapy-induced apoptosis targeting Toll-like receptor 2 expression [28]. The gene discussed is TLR2; the disease is acute myeloid leukemia.