Other information derives from the net composed by 5 TFs (KLF2, CEBPB, CEBPD, JUND, and JUNB), all upregulated and closely implicated in NDs like AD, ALS, SCA, and PD (Evert et al. 2006; Wu et al. 2013; Doxakis 2020; Sun et al. 2022; He et al. 2023). This evidence concerns the gene KLF2 and amyotrophic lateral sclerosis.