Indeed, the functional bioinformatic analysis performed in our study pointed to a significant downregulation of the immune system during SMA (Fig. 4A–C) represented by enriched terms concerning, e.g., MHC class II protein complex and binding, auto/immune diseases (thyroid, type-1 diabetes, graft-versus host), intestinal immune network for IgA production. This evidence concerns the gene CD79A and thyroid gland disorder.