KLF2 and amyotrophic lateral sclerosis: Since depletion of KLF2 (the encoding gene being one of the top genes with highest MCC score measuring its centrality in the net) was reported to cause enhanced apoptosis NGF-mediated (Dutta et al. 2011), while overexpression of the two TFs CEBPB and CEBPD significantly characterized ALS (Sun et al. 2022), and JUND is one of the “allegedly restored” gene by nusinersen in our study, it is reasonable to hypothesize that the interaction between them—possibly mediated by miRNAs like miR-532-3p—could be critically involved also in SMA.