Altogether, our observations indicate that STAT1 responsiveness by CD11c+ cells is crucial for HK-fbp1 vaccine-induced protection against virulent challenge with H99 via effects that include (i) promoting protective innate responses characterized by higher Mo-DCs and low eosinophilia, (ii) protective Th1 expansion in the MLN and infiltration to the airways, and (iii) control of fungal dissemination from the lung. The gene discussed is STAT1; the disease is Increased total eosinophil count.