Altogether, our observations indicate that STAT1 responsiveness by CD11c+ cells is crucial for HK-fbp1 vaccine-induced protection against virulent challenge with H99 via effects that include (i) promoting protective innate responses characterized by higher Mo-DCs and low eosinophilia, (ii) protective Th1 expansion in the MLN and infiltration to the airways, and (iii) control of fungal dissemination from the lung. This evidence concerns the gene ITGAX and Increased total eosinophil count.