CD8A and lung carcinoma: Using tertiles for the lung cancer analysis (due to smaller number of cases), there was a dose–response but not a statistically significant relationship for Treg and memory B-cell proportion, whereas for naïve CD8+ cell proportion, a statistically significant relationship was observed for the highest tertile when compared with the lowest tertile (HR, 0.47; 95% CI, 0.25–0.87; Supplementary Table S10).