Administration of PADI4i (Figure S7D, Supporting Information) reversed the destructive impacts of chronic stress in both CAA‐ and WT‐CRS mice, including Aβ40 deposition (Figure 4D), declined ZO1 expression (Figure 4E), myelin loss (Figure 4F) and cognitive decline (Figure S8, Supporting Information). This evidence concerns the gene TJP1 and Mental deterioration.