Due previous studies showed that the mutant p53 protein may form complexes and calculate in the nucleus, which can protect mutant p53 protein from degradation and promote tumor progression.[19, 20, 21] We separated the nuclear and cytoplasmic proteins and found that nuclear p53R156P was decreased and the ratio of cytoplasmic p53R156P to nuclear p53R156P was increased in the LACTBM5L+R469K knockdown group (Figure 5E,F; Figure S7A, Supporting Information). Here, TP53 is linked to neoplasm.