LACTB has been reported to be a tumor suppressor in breast cancer.[3] Contradictory to the results of existing research, our preliminary study identified LACTB as a super enhancer associated gene that promoted tumor progression in OS models.[10, 11] In the present study, by performing western blot and immunofluorescence, we found that OS tissues had markedly higher LACTB protein expression levels than peritumoral tissues did (Figure 1A; Figure S1A‐C, Supporting Information). This evidence concerns the gene LACTB and neoplasm.