Because missense mutation in TP53 might invalidate or even reverse its tumor suppressive function, we ensured that U2‐OS and SJSA‐1 cells contained wt‐p53 via the TP53 Database (R20, July 2019: https://tp53.isb‐cgc.org).[17] We screened the RNA‐seq data and found that downstream factors of the TP53 pathway, but not the TP53, were markedly altered (Figure 3C), and we validated this result subsequently (Figure 3D). This evidence concerns the gene TP53 and neoplasm.