reported that LACTB was highly expressed in the nasopharyngeal carcinoma tissues and promoted metastasis via activation of ERBB3/EGFR‐ERK pathway.[9] In our preliminary study, we also identified LACTB as a super enhancer associated gene and unexpectedly revealed that high level of LACTB indicated poor prognosis in osteosarcoma (OS).[10, 11] These studies suggest that LACTB can function either as an oncogene or as a tumor suppressor, although the mechanisms underlying its opposite roles in tumor are not well understood. This evidence concerns the gene ERBB3 and neoplasm.