The mutation of TP53 may abrogate the tumor suppressive ability of p53 or even lead to gain of function (GOF).[29, 30, 31] Several studies have shown that the mutant p53 protein is difficult to be degraded via the ubiquitin‐proteasome system and may form complexes in the nucleus to promote tumor progression.[19, 20, 21] Alexandrova et al. Here, TP53 is linked to neoplasm.