By further functionalization using hyaluronic acid (HA) and MMP2 substrate‐linking P3 peptide‐modified HA (P3‐HA), an enhanced anti‐obesity effect is obtained by dual‐targeting of P3 and HA, and HA‐mediated CD44 poly‐clustering after MMP2 cleavage. The gene discussed is MMP2; the disease is obesity disorder.