Furthermore, ANGPT2 mRNA was increased in the glomeruli of patients with diabetic nephropathy (Dessapt‐Baradez et al., 2014; Shi et al., 2018) and a decrease in Ang‐1/Ang‐2 ratio contributed to disease progression in preclinical animal models of DKD (Rizkalla et al., 2005; Yamamoto et al., 2004). This evidence concerns the gene ANGPT1 and diabetic kidney disease.