Progression of microvascular complications in DKD is complex and emerging evidence support an important role of endothelium‐specific Tie2 (tyrosine kinase with IgG and EGF homology domains 2) receptor, Angiopoietin‐1 (ANGPT1 or Ang‐1) and Angiopoietin‐2 (ANGPT2 or Ang‐2) ligands. This evidence concerns the gene ANGPT1 and diabetic kidney disease.