GFAP‐Cre; RBlox/lox; p53lox/lox mice developed medulloblastoma at a high penetrance, and provided direct proof of the developmental origin of medulloblastoma [54], and later studies showed that Myc amplification leads to a large cell anaplastic phenotype, striking parallel to human medulloblastoma [148, 149, 150]. Here, MYC is linked to medulloblastoma.