A follow‐up study utilised IGF2 signalling and Akt (Akt‐Myr‐D11‐60) activation, creating medulloblastoma with approximately 50% incidence when combining RCAS Shh and IGF2 or Shh and IGF2, in NTVA mice in a Ptc wild‐type background [93]. Here, SHH is linked to medulloblastoma.