Delivering PDGF and Cre‐recombinase by retroviral or lentiviral vectors, these models developed rapidly growing high‐grade gliomas at high penetrance, making them highly suitable for analysis of glioma‐associated pathways such as Notch signalling [158], IDH mutation [159] or for the generation of versatile preclinical models [160, 161, 162]. Here, IDH1 is linked to central nervous system cancer.