This model confirmed previous studies (using a different approach to express mutant IDH1 [114, 115]), in that the sole expression of mutant IDH1 in nestin‐expressing precursor cells does not lead to tumour formation in the lifetime of these mice (delivery of RCAS‐Cre and RCAS‐IDH1R132H into NTVA; Cdkn2alox/lox; Atrxlox/lox; Ptenlox/lox mice). This evidence concerns the gene IDH1 and neoplasm.