Expression of Cre‐recombinase under the control of the human GFAP promoter in mice with combined recombination of Pten and p53 (Gfap‐Cre, PTENlox/lox; p53lox/lox) [133] causes the formation of diffuse high‐grade glioma, morphologically resembling human glioblastoma. Here, PTEN is linked to central nervous system cancer.