The discovery that stem/progenitor cells of the CNS (termed B‐type of SVZ, [154]) express platelet‐derived growth factor receptor alpha (PDGFRA), and respond to stimulation with PDGF with hyperplasia with features of gliomas [155, 156, 157], formed the basis of experimental approaches combining PDGF receptor stimulation (either by expressing the receptor or the ligand) in combination with Cre‐recombinase, in the context of tumour suppressor gene models, such as conditional Ptenlox/lox, Rblox/lox, or p53lox/lox mice. This evidence concerns the gene PDGFRA and central nervous system cancer.