SHH and neoplasm: Subsequent medulloblastoma models further explored other pathways which had been identified in human medulloblastoma, such as BCL2 (combining Bcl2 and Shh expression in the background of NTVA mice, resulting in nearly 80% tumour induction rate [95]), and also a high frequency (80%) of medulloblastoma formation in mice after postnatal expression of hepatocyte growth factor, the ligand of the met receptor in cooperation with Shh [96].