PTEN and central nervous system neoplasm: Instead, no CNS tumours were found in heterozygous p53 mutants (soft tissue sarcomas and haematological neoplasms) [73], Apc (colorectal tumours, [74, 75]), or Pten (Lymphomas, dysplastic intestinal polyps, endometrial complex atypical hyperplasia, prostatic intraepithelial neoplasia, and thyroid neoplasms [76]).