COMP and schizophrenia: Two of the associations were with Depressed mood in the Community cohorts: rs55780333 (p = 1.78 × 10−8), an intron in COMP (ENSG00000105664, cartilage oligomeric matrix protein) also near CRTC1 (ENSG00000105662, CREB regulated transcription coactivator 1), a gene that regulates metabolism and results in social withdrawal behaviors when knocked out in a mouse model (Breuillaud et al., 2012); and rs28665026 (p = 2.13 × 10−8) in an intron in an uncharacterized gene (LOC107986777) and associated with schizophrenia (Trubetskoy et al., 2022).