Subjects in the higher quartiles of DII and DIL had a higher prevalence for NAFLD and had higher age, energy intake, weight, height, BMI, waist circumference, FBS, fasting insulin, HOMA-IR, HOMA-B, LDL, TAG, TC, systolic blood pressure, diastolic blood pressure and liver enzymes (ALT, AST, GGT) but lower levels of physical activity, HDL and frequency of females (P < 0·05). This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.