At ten months post-infection, unvaccinated patients had 53 overexpressed proteins involved in humoral immune response, innate immune response, immune effector process, and inflammatory response (C3b, CCL15, IL17RE, KRT1, DEFA5, TREM1), while vaccinated patients had 25 overexpressed proteins involved in cellular response to chemical stress (PSMA5), peroxisomal protein import, and folate metabolism compared with HC (Figure 5E). This evidence concerns the gene DEFA5 and infection.