Of interest, we identified a CD20+CXCR4hi metacluster expressing CD40 and CD4 compared to HIV-negative samples (MC19) and a significant expansion of CD20+CXCR4hiCD27+CD24+CXCR5+CD4+cMYC+IgMhi HLA-DR+ B cells (MC15) compared to HIV-negative and HIV+ pre-NHL (cART-naïve) samples (Supplementary Table 7). The gene discussed is CD4; the disease is non-Hodgkin lymphoma.