We then evaluated whether the CD20+CD27+CD24+CD40+CXCR4+CXCR5+ B-cell populations expressing cMYC and AICDA in HIV+ pre-NHL (cART-naïve) samples (MC14 and MC21) had a potentially clonal origin by examination of Ig kappa and lambda light chain (LC). Here, CXCR4 is linked to non-Hodgkin lymphoma.