The third elevated Breg population in HIV+ pre-NHL (cART-naïve) samples also expressed CD20, CXCR4, CXCR5, CD40; were cMYC+; and were uniquely AICDA+ and CD4+ compared to HIV+ cART-naïve samples (MC03) (Figure 6F). The gene discussed is CXCR5; the disease is non-Hodgkin lymphoma.