The purpose of this study was to conduct unsupervised clustering analysis of CD19+ B cells and describe phenotypically distinct B-cell populations in HIV+ cART-naïve and HIV+ pre-NHL (cART-naïve) that went on to develop NHL (median of 12 months before NHL diagnosis) (Supplementary Table 2). The gene discussed is CD19; the disease is non-Hodgkin lymphoma.