The CD20+CD27+CD24+CD40+CXCR4+CXCR5+ B cells identified in MC21 of HIV+ pre-NHL (cART-naïve) samples also had a potential pre-lymphoma phenotype (cMYC+ and AICDA+), were FoxP3+, and had higher CD27 expression compared to its respective metacluster population in MC21 of HIV+ cART-naïve samples (p = 0.020) (Figure 3D and Supplementary Table 5). Here, CD27 is linked to non-Hodgkin lymphoma.