Supplementary Figure 2B provides histogram overlays of different markers of B-cell activation and/or differentiation, and oncogenic markers analyzed in this study. We performed unsupervised clustering on 75,000 CD19+ B cells per group using UMAP for dimension reduction and FlowSOM clustering algorithms in OMIQ. High-dimensional analysis of CD19+ B cells revealed 60 metaclusters in HIV-negative, HIV+ cART-naïve, and HIV+ pre-NHL (cART-naïve) samples (Figures 1B, C). This evidence concerns the gene CD19 and non-Hodgkin lymphoma.