The CD20+CXCR4+PD-L1+ B cells in MC12 and MC14 of HIV-negative samples displayed higher Bcl-6 expression compared to HIV+ cART-naïve (p = 0.009, MC12 and p = 0.003, MC14) and HIV+ pre-NHL (cART-naïve) (p = 0.011, MC12 and p = 0.001, MC14). The gene discussed is BCL6; the disease is non-Hodgkin lymphoma.