We found that CD20+CD27+CD24+CXCR4+CXCR5+ B cells, CD20+CD27+CD10+CD24+ CXCR4+cMYC+ B cells, and populations of CD20+CD27- B cells were significantly elevated in HIV+ pre-NHL (cART-naïve) compared to HIV+ cART-naïve samples (Figure 3C and Supplementary Table 4). The gene discussed is CXCR5; the disease is non-Hodgkin lymphoma.