The second elevated Breg population in HIV+ pre-NHL (cART-naïve) samples expressed CD20, CXCR5, CD40, and FoxP3; were cMYC+; and were uniquely AICDA+ compared to HIV+ cART-naïve samples (MC04) (Figure 6F). This evidence concerns the gene CXCR5 and non-Hodgkin lymphoma.