CXCR4 and diffuse large B-cell lymphoma: The high expression of CXCR4 has been significantly associated with poor outcome of R-CHOP-treated DLBCL patients, and it was found to be an independent factor predicting poorer progression-free survival in germinal-center B-cell-like DLBCL (54), and shorter overall survival and progression-free survival in DLBCL patients (55).