In addition, significantly elevated levels of CD20highCXCR4+Bcl-6+ B cells with low-level CD4 and CD8 expression were identified in HIV+ cART-naïve samples (MC14) [CD20 marker expression: HIV+ cART-naïve vs. HIV+ pre-NHL (cART-naïve), p = 0.040]. This evidence concerns the gene CD4 and non-Hodgkin lymphoma.