Although significantly lower levels of CD20+CD27+CD24+CD40+CXCR4+CXCR5+ B cells were observed in MC14 of HIV+ pre-NHL (cART-naïve) samples, these cells had a potential pre-lymphoma phenotype as they expressed both cMYC and AICDA compared to HIV+ cART-naïve and HIV-negative samples (Figure 3D and Supplementary Table 5). This evidence concerns the gene CXCR4 and non-Hodgkin lymphoma.