We found that B-cell populations with aberrant features (CD20+CD27+CD10+CD24+CXCR4+cMYC+ B cells and CD20+CXCR4hiCD27-CD24+CXCR5+CD40+CD4+AICDA+ B cells) and Bregs expressing AICDA and cMYC were in the circulation of HIV+ pre-NHL (cART-naïve) compared to HIV+ cART-naïve individuals. This evidence concerns the gene CD4 and non-Hodgkin lymphoma.