Moreover, 4 of the 10 HIV+ pre-NHL (cART-naïve) samples had metaclusters of CD20+CD27+CD24+CD40+CXCR4+CXCR5+ B cells (MC21) that were positive for both Ig kappa and Ig lambda LC (median expression value of Ig kappa LC = 1.15 vs. median expression value of Ig lambda LC = 4.50; p = 0.029). The gene discussed is CD40; the disease is non-Hodgkin lymphoma.