In addition, we found that the CD20+CXCR4+CXCR5+ B-cell population in MC14 of 1 of the 10 HIV+ pre-NHL (cART-naïve) samples were potentially of clonal origin as they specifically showed Ig kappa LC positivity, and this clone had potential pre-lymphoma characteristics as it expressed both cMYC and AICDA. The gene discussed is CXCR4; the disease is non-Hodgkin lymphoma.