CD8A and persistent truncus arteriosus: In addition, we recently demonstrated that CD11c+ dendritic cells (DCs) were significantly increased in HF mice, and depletion of CD11c+ DCs significantly attenuated TAC-induced activation of CD4+ and CD8+ T cells, and depletion of CD11c+ cells also effectively attenuated TAC-induced LV hypertrophy and dysfunction in mice (14).