In contrast, the spleen CD4+ Tem, naïve CD4+ T cells, central memory CD4+ T cells, and CD4+CD44-CD62L- T cells were largely unaffected by Treg depletion in HF mice, with or without concurrent CD8+ T cell depletion (Supplementary Figures S9E–H). The gene discussed is CD8A; the disease is hydrops fetalis.