From a genetic perspective, schizophrenia and T2DM have a significant genetic correlation (12), one compelling piece of evidence is the transcription factor 7-like 2 (TCF7L2) gene, which is identified as one of the most significant risk genes for T2DM (13), also has a significant contribution to schizophrenia (14). This evidence concerns the gene TCF7L2 and schizophrenia.