Our experimental results demonstrate that the PNPLA3 rs738409 GG variant LAMPS exhibits increased steatosis in NF, EMS, and LMS media compared to the wild-type CC LAMPS, consistent with the clinical characterization describing abnormal lipid homeostasis in these patients (Romeo et al., 2008; Mann and Anstee, 2017; Mann et al., 2020; Luukkonen et al., 2023; Luukkonen et al., 2019). The gene discussed is PNPLA3; the disease is steatosis.