The PNPLA3 polymorphism is associated with increased susceptibility to MASLD, disease progression to cirrhosis, and risk of developing HCC, and prior research supports the incorporation of the PNPLA3 genotype into prognostic scores for predicting the risk of disease progression (Kabbani et al., 2022; Krawczyk et al., 2020). The gene discussed is PNPLA3; the disease is Cirrhosis.