Exosomal lnc-MZT2A-5:1, derived from AZD9291-resistant NSCLC cell lines, has the ability to enhance the activation of MRC-5 fibroblast cells, which are a significant cell type in the tumor microenvironment and have a vital role in the malignant characteristics of NSCLC. The gene discussed is MZT2A; the disease is non-small cell lung carcinoma.