Exosomal lnc-MZT2A-5:1, derived from AZD9291-resistant NSCLC cell lines, has the ability to enhance the activation of MRC-5 fibroblast cells, which are a significant cell type in the tumor microenvironment and have a vital role in the malignant characteristics of NSCLC. This evidence concerns the gene CD200 and non-small cell lung carcinoma.