EGFR and neoplasm: There was a marked rise in the levels of exosome-derived miR-3913-5p and miR-184 after the initiation of osimertinib resistance.miR-3913-5p and miR-184 demonstrated greater utility in predicting resistance to osimertinib in patients with EGFR exon 21 L858R point mutations than exon 19 deletion.miR-3913-5p correlated with other tumor parameters, including platelet count, Tumor, Node, Metastasis (TNM) stage, carcinoembryonic antigen tumor marker, and the presence of distant metastases.