Following univariate COX-regression analysis (Table 2), the main clinical/pathological factors showing significant correlations with a low overall-survival value were: de novo metastatic disease (p=0.001); distant recurrence (p=0.003); first-line therapy (p<0.001); stage-IV disease (p=0.01); high levels of the mRNAs involved in the EMT process (CDH1 and ZEB1) (p=0.001) and high levels of TP53 (p<0.001). This evidence concerns the gene TP53 and metastatic neoplasm.