This last observation supports the idea that advanced and high-stage stomach tumors contain large amounts of RARα, RARβ, RXRα and RXRβ. The determination of possible associations with the gastric cancer molecular features, which we examined, are substantially in line with the concept that RARα/RARβ/RXRα/RXRβ levels correlate with MSS, EMT and TP53 expression in a positive manner. This evidence concerns the gene TP53 and gastric neoplasm.