As for the RXR transcripts (Figure 4), high expression levels of the RXRα mRNA showed significant correlations with: stage-IV disease (p<0.001), de novo metastatic disease (p<0.001), MSS status (p=0.001), EMT (p<0.001) as well as the amounts of the TP53 (p< 0.001), CDKN1A (p=0.001) and PIK3CA (p<0.001) transcripts. Here, PIK3CA is linked to metastatic neoplasm.