PIK3CA and metastatic neoplasm: In addition, the RXRβ mRNA moved in association with stage-IV disease (p=0.003), de novo metastatic disease (p=0.003), MSS status (p< 0.001), EMT (p<0.001) and high levels of TP53 (p<0.001) as well as PIK3CA (p=0.002).