The interaction between Aβ and ApoE in the lipid rafts is also vital for neurofibrillary tangle formation, highlighting the importance of these membrane domains in AD pathogenesis, as well as the potential of targeting cholesterol synthesis in astrocytes as a therapeutic approach to mitigate amyloid and tau pathology (Wang et al., 2021; Yin et al., 2019; Kojro et al., 2001; Lee et al., 1998; Wahrle et al., 2002; Oshima et al., 2001; Kawarabayashi et al., 2004; Riddell et al., 2001). Here, MAPT is linked to Alzheimer disease.