The authors developed a web application to assess the risk of AL in real time during the intraoperative period, taking into account several factors; such as: age, BMI, comorbidities, previous lower abdominal surgery, tumor obstruction, pre-operative hemoglobin level (g/dl), preoperative albumin level (g/L), electrolyte disorder, tumor size (cm), distance between the lower edge of the tumor and the anal edge (cm) and operative time (min) (28). This evidence concerns the gene ALB and neoplasm.