Currently, miR-223, miR-101, KPNA2 and E2F1 have been identified as regulators of STMN1 in HCC (Wong et al., 2008; Wang et al., 2014; Xu et al., 2013; Zheng et al., 2015; Drucker et al., 2019; Chen et al., 2013). This evidence concerns the gene E2F1 and hepatocellular carcinoma.