GDI2 and cancer: CRC possesses the common biological characteristics of most malignant tumors, including malignant proliferation, invasion, migration, and high levels of angiogenesis [24].In this study, we first examined clinical specimens by qRT-PCR assay and immunohistochemical assay, and based on bioinformatics analysis of the TCGA database, we investigated the expression differences and effects of GDI2 in CRC tissues.