To verify the effect of GDI2 expression on the cell cycle, the cell cycle phase distribution of each group was detected by flow cytometry, and the analysis results were shown in Table 1, Table 2, and Fig. 4D. Compared with the sh-NC group, the percentage of G0/G1 phase cells in CRC cells in the sh-GDI2 group was increased (P < 0.01). Here, GDI2 is linked to colorectal carcinoma.