Additionally, investigations by Kurhanewicz et al. revealed that exposure to acrolein led to cardiac autonomic imbalance and arrhythmia in wild-type mice (54, 55), which was absent in Trpa1−/− mice, underscoring the crucial role of TRPA1 in mediating the cardiovascular effects of acrolein exposure. The gene discussed is TRPA1; the disease is Postural instability.