When compared to the reference chemical, 1,4-dimethyl-4-pententyl acetate had a higher affinity for the progesterone receptor when compared to the reference compound (5-fluorouracil). In hormone-dependent malignancies such as endometrial and breast cancer, progesterone receptors play a critical role by stimulating cell division and preventing apoptosis. The discovery of lead compounds that target progesterone receptors is an emerging area of research in cancer therapy. The gene discussed is PGR; the disease is breast carcinoma.