SIRT1 and myocardial ischemia: First, Sal B can further induce NLRP3 inactivation by inhibiting intracellular ROS production during myocardial ischemia, increasing the mitochondrial membrane potential, regulating the expression levels of SIRT1, Parkin, and PINK1 proteins, and promoting mitochondrial autophagy (Hu et al., 2020).