GSK3B and cancer: Mishra et al. reported that overexpression of GSK3B plays a greater role in oral squamous cell carcinoma (OSCC) than in other cancers due to the activation of the downstream transcription factor GSK3B, which promotes uncontrolled cell division in OSCC, suggesting a link between the occurrence of OSCC and increased GSK3B expression (Mishra et al., 2015).