TP53 and hepatocellular carcinoma: For example, ICT can treat OC by regulating the p53/AKT/mTOR signaling pathway (Gao et al., 2018), inhibit breast cancer cell proliferation through MAPK/ERK signaling pathway (Wang et al., 2017), and treat HCC by inducing ROS production and cell cycle arrest (Wang et al., 2019).