ACP5 and osteoporosis: Based on the glucocorticoid (GC)-induced osteoporosis (GIOP) model in rats, researchers found that oral administration of Epimedium and Fructus Ligustri Lucidi (100, 200 mg/kg/day) increased levels of bone formation markers such as alkaline phosphatase (ALP), bone γ-carboxyglutamic acid-containing protein (BGP), and bone mineral content (BMC), while decreasing levels of tartrate-resistant acid phosphatase (TRACP) secreted by osteoclasts.