TNFRSF10C, an antagonistic receptor protecting cells from TRAIL-induced apoptosis, is an example, and its genomic deletion and promoter hypermethylation have been found in a variety of cancers, including pancreatic [27], prostate [28], colon [29], lung [30], breast [31], bladder [32] cancers. Here, TNFRSF10C is linked to cancer.