As a significant predictor of cardiovascular diseases, high hs-CRP levels are involved in both localized and systemic inflammatory responses, impairing endothelial cells, reducing NO and prostaglandin release, upregulating Angiotensin I receptors, and affecting renin and angiotensin levels, which contribute to endothelial cell proliferation, intimal thickening, and arteriosclerosis progression (25, 26). This evidence concerns the gene REN and cardiovascular disorder.