Mutations causative for one form of familial amyotrophic lateral sclerosis (ALS)—an adult-onset neurodegenerative disorder leading to loss of upper and lower motor neurons—lie within the RNA/DNA-binding protein fused in sarcoma/translocated in liposarcoma (FUS/TLS) [67,68], which can interact with TBP and may influence RNA polymerase II and the TFIID complex assembly, among other roles in transcription [69,70]. This evidence concerns the gene TBP and Adult onset.