Interestingly, Cheng et al. report the difference in Gibbs free energy change for XLID-associated mutations in the TAF1-TAF7 binding domain compared with the WT molecule, where many mutations such as p.Gly680Asp (reported in one female only), p.Phe853Val and p.Arg870Cys showed no differences, whereas p.Arg707Pro shows a positive change indicating that it destabilizes the protein structure [58]. The gene discussed is TAF1; the disease is cask-related x-linked intellectual disability.