Integrin activation can lead to the autophosphorylation of focal adhesion kinase (pFAK), initiating mechanotransduction through the MAPK/ERK pathway and activating downstream molecules like Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ), β-catenin, serum response factor (SRF), and megakaryocytic acute leukemia (MAL), resulting in gene expression alterations.183–186. Here, SRF is linked to acute leukemia.